[Retracted] MicroRNA­137 has a suppressive role in liver cancer via targeting EZH2.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the Transwell cell migration assay data shown in Fig. 2D and 6D, and the scratch­wound assay data in Figs. 2E and 6E, were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to Molecular Medicine Reports, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive any reply. The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 16: 9494­9502, 2017; DOI: 10.3892/mmr.2017.7828].

Coalescence and wetting mechanism of Al droplets on different types of carbon for developing wettable cathodes: a molecular dynamics simulation.

So far, there have been few studies on the microscopic wetting behavior of aluminum liquid on cathode surfaces, which is critical for developing wettable cathode materials. In the present study, an investigation on the coalescence and wetting mechanism of Al droplets on different carbonaceous substrates has been performed via molecular dynamics (MD) simulation for developing wettable cathodes. The growth rate of liquid bridge, the mean squared displacement, the balanced contact angle, and the time of full coalescence were calculated to describe the coalescence and wetting of the Al droplets. The results illustrate the sequence of full coalescence time for the Al droplets: DG < HCNT < VCNT ≈ AC and the corresponding balanced contact angles were 47.98°, 53.32°, 55.02°, and 63.12°, respectively. Furthermore, the presence of defects on DG will increase the time of coalescence and the contact angle but the directions of defects have little influence. The free energy analysis indicates that the defects reduce the solid-liquid interaction and the work done for removing the Al droplet from the substrates so that the wettability is weaker than that for perfect graphene, which also explains the balanced wettability of Al droplets on the other substrates. In addition, the surface roughness increases the contact angle of Al liquid on AC (from 62° to 113°-120°) and hence, the wettability is changed from good to poor. In general, our results can improve the understanding of the wetting of AC and graphene by Al liquid at the atomic level, which can provide direction and theoretical guidance for further research on wettable cathodes.

[Corrigendum] MicroRNA-137 has a suppressive role in liver cancer via targeting EZH2.

Following the publication of this article, we realize that an error was made with the second author's (Yanlei Sun's) address: This should have been written as "Department of General Surgery, Cancer Hospital of Linyi, Linyi, Shandong 276001", not as "Department of General Surgery, Central Hospital of Linyi, Linyi, Shandong 276400". Therefore, the author affiliations and addresses in this paper should have appeared as follows: SHICHANG CUI1, YANLEI SUN2, YANG LIU3, CHENGBIAO LIU1, JINBAO WANG1, GUANG HAO1 and QIDONG SUN1 1Department of General Surgery, Central Hospital of Linyi, Linyi, Shandong 276400; 2Department of General Surgery, Cancer Hospital of Linyi, Linyi, Shandong 276001; 3Department of Obstetrics and Gynecology, Central Hospital of Linyi, Linyi, Shandong 276400, P.R. China. The authors regret this error in the affiliation, and apologize for any inconvenience caused. [the original article was published in the Molecular Medicine Reports 16: 9494-9502, 2017; DOI: 10.3892/mmr.2017.7828].

MicroRNA­137 has a suppressive role in liver cancer via targeting EZH2.

A variety of microRNAs (miRs) have been demonstrated to be associated with the development and malignant progression of human cancer; however, the regulatory mechanism of miR­137 underlying hepatocellular carcinoma (HCC) growth and metastasis still remains to be fully revealed. In the present study, reverse transcription­quantitative polymerase chain reaction and western blot were used to examine mRNA and protein expression. MTT assay, wound healing assay and Transwell assay were performed to determine cell proliferation, migration and invasion. Luciferase reporter assay was conducted to confirm the targeting relationship. miR­137 was significantly downregulated in HCC tissues compared to adjacent normal tissues. Low expression of miR­137 was significantly associated with lymph node metastasis, vein invasion, advanced clinical stage and poor prognosis in HCC. In addition, miR­137 was also downregulated in several liver cancer cell lines compared with normal liver epithelial cells. Overexpression of miR­137 led to a significant reduction in cell proliferation, migration and invasion of HepG2 cells. Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) was further identified as a direct target gene of miR­137, and the protein expression of EZH2 was negatively regulated by miR­137 in HepG2 cells. Additionally, EZH2 was significantly upregulated in HCC tissues and liver cancer cell lines. Furthermore, overexpression of EZH2 significantly eliminated the inhibitory effects of miR­137 on the malignant phenotypes of HepG2 cells. Therefore, the findings suggest that miR­137 may have a suppressive role in HCC growth and metastasis via targeting EZH2.